Antibody Dependent Enhancement: What in the World is That?

Antibody Dependent Enhancement

Antibody Dependent Enhancement, or ADE for short!

Erin Stair, MD, MPH

There are several viral videos with millions of views referencing something called Antibody Dependent Enhancement (ADE) as a potential effect of COVID-19 vaccines or vaccines in general. Some make very bold claims and it’s difficult to sort fact from fiction from hyperbole in these videos. I watched one video with a family medicine doctor who claimed the vaccine was a depopulation effort. The video’s gone viral, and I’ve already seen it on several wellness sites. To me, the video felt unscientific and exaggerated for the selfish purpose of making the video go viral, but…perhaps, rooted in a bit of truth. And guys, I do not buy the theory that the vaccine is a “depopulation plan.” Here’s why: These vaccines are high-tech, expensive and hard to distribute. As Darwin has it, only rich countries will get the vaccines at first, and our birth rates are way down. In fact, some public health people think our declining birth rate is a public health crisis in the making. If you wanted to depopulate the world with this vaccine, you wouldn’t give it to the rich countries. You’d give it to the poor countries that have significantly higher birth rates. But I digress… ūüėČ

If you read my blog on the COVID-19 vaccines, which is basically the mother-of-all cheat sheets when it comes to everything I know ( and don’t know) about these vaccines, I ask the question someone asked me: “What was your biggest concern about the COVID vaccines?” The answer I wrote down was “Antibody Dependent Enhancement.” It still is my greatest concern. My research on vaccines and COVID-19 led me to scientific papers on past attempts to develop a vaccine for any coronavirus. I specifically looked at the vaccine trials for MERS and SARS, a coronavirus that is similar to COVID-19. Those vaccine trials never made it beyond the pre-clinical (or animal) stage, because of something called Antibody Dependent Enhancement. This phenomenon is not easy to understand, but in very, very simple terms, it’s when vaccine-induced antibodies enhance, or make worse, a viral infection when exposed to the virus AFTER being vaccinated for it. In short, it’s not good and quite bad, and we wouldn’t know it was happening for months after the vaccines hit the population.

To be fair, I have read all of the Emergency Use Applications for the COVID-19 vaccines, and long-term monitoring of Antibody Dependent Enhancement of Disease is part of their plan. Certainly the FDA will not approve these vaccines until ADE is ruled out. Of course, the FDA and CDC will be monitoring other potential side effects and the safety and durabilty of these vaccines for a long time before granting them Approval. I reached out to several authors of the papers on Antibody Dependent Enhancement, and asked if they’d be willing to do a podcast on this topic to help us understand it better and dispel fear-mongering rumors. They either 1) didn’t respond to me 2) told me no 3) told me they’d love to talk about it on my podcast, but their institution wouldn’t let them. That last one irked me. I can’t say for sure it was censorship, but it certainly smelled like it. Anyhow, one of the researchers who wanted to come on my podcast but “wasn’t allowed,” gave me the name of a top vaccinologist and scientist who “might” be willing to do the podcast. That was Dr. Robert Malone. I reached out to him, we agreed to have a phone call first and then he did the podcast. I am SO glad he did, because the podcast is incredibly informative, scientific, HONEST and easy-to-understand. A lot of folks have messaged me after listening to the podcast and were beyond complimentary. It’s already one of my top 3 listened-to podcasts.

On the podcast, we chatted about Antibody-Dependent Enhancement and how it relates to vaccine development. Dr. Malone explains how vaccine-induced ADE happens, using a fork as a metaphor. He also discusses vaccine development in general, the COVID vaccines, how one would design a study to rule out Antibody Dependent Enhancement, how to figure out if it’s happening in the population and what to do if it is happening. This isn’t fear-mongering. It’s honest science from a highly-qualified expert being honest about risk.

Who is Dr. Malone?

Dr. Malone is a physician, vaccinologist, scientist and internationally recognized as one of the original inventors of¬† “DNA Vaccination.” He has done extensive research and clinical development in the areas of clinical trial design and vaccines, gene therapy, biodefense and immunology.¬† In 2014, he built and led the initial team, under NewLink Genetics, that took the Canadian rVSVZEBOV-G Ebola vaccine from an abandoned vaccine candidate to a viable contender and eventually a successful vaccine for Ebola. He has worked with numerous high-level government and private organizations and has been involved in the design, development and oversight of over 40 Phase 1 Clinical trials, 20 Phase 2 clinical trials and 5 Phase 3 trials. His infectious disease pathogen advanced development oversight include HIV, Influenza, Plague, Anthrax, Tularemia, Tb, Ebola, Zika, Ricin toxin, Botulinum toxin and engineered pathogens. He has over 100 peer-reviewed papers, over 11 thousand citations and has sat on or served as chairperson on many NIAID and DoD study sections. You can learn more about his consulting firm and¬†background here.

Please keep in mind that this podcast is information only and never to be taken as medical or health advice. If you’re ready to listen, click here!

Oh, one more thing: Dr. Malone and his wife wrote a book about COVID-19 and self-published it to Amazon. I talk about that book in the podcast, because he sent me a PDF copy, which I read before the podcast. Some of you asked me where you can get his book. Unfortunately, Amazon pulled the book and stopped publishing it. They didn’t give the Malones a reason why, and after reading the book, I couldn’t give you one good reason this book deserved to be banned. Maybe Amazon could explain themselves one day: Upholding a narrative? Censoring? Didn’t like the cover? Don’t like them? I don’t know why Amazon did it, but I will say this: Banning books is never indicative of a healthy society.

Anyhow, hope you guys listen to the podcast and if you have any questions or comments, do not hesitate to contact me.

Listen here!

Xo, Erin

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One Response to “Antibody Dependent Enhancement: What in the World is That?”

  1. Thank you!! I found this super informative and clear. Thanks for bringing on Dr. Malone and the insightful conversation.

    I’m also curious to learn more about ADE and found a few other researchers who discuss it honestly though being in favorable support of the benefits vs the risks (like you say, discussing ADE not as fear-mongering, but as something to simply pay attention). Here is one other researcher I found:

    Would be great to hear a part 2 of Dr. Malone!

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